Nowadays, smart and fast services to patients and move on to the next generation hospital are the essential parts of the health field. The production of information technology architecture for hospital organizations is the foundation of accessible smart services and providing services with more speed and higher quality than the traditional systems. In this paper, the target is to present an indigenous IT architecture based on important criteria and metrics in Iranian hospitals. The TOGAf architecture is used and then it is adopted and localized for Shariati hospital based on Iran’s indigenous conditions. For this aim, expert’s views and 134 questionnaire tools are applied and the results are analyzed through suitable statistical tests. So IT architecture is designed by consisting up a conceptual model of four input and four infrastructure layer. The results show that 111 items are verified to apply to the hospital among 145 possible items. The customization framework is called the Hospital IT Architecture. The components provide the framework approved in 8 layers and 11 components can be used in hospitals to implement enterprise architecture. The proposed architecture in 8 layers and 11 components are designed and it could be applied as an indigenous reference architecture for implementation of enterprise architecture in Iranian Hospital organizations.

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